Table 3.
Drinking categories | N/na | Weighted Mean RRb | Partially adjusted mean RRc | Fully adjusted mean RRd | ||||||
---|---|---|---|---|---|---|---|---|---|---|
RR & 95 % CI | t–test P | RR & 95 % CI | t–test P | RR & 95 % CI | t–test P | |||||
Abstainer | 1.00 | 1.00 | 1.00 | |||||||
Former drinker | 7/13 | 1.14 | 0.99 – 1.30 | 0.0642 | 1.12 | 0.98 – 1.29 | 0.0990 | 1.10 | 0.97 – 1.25 | 0.1348 |
Occasional (<1.30 g/day) | 6/7 | 0.97 | 0.86 – 1.10 | 0.6126 | 0.96 | 0.85 – 1.08 | 0.5265 | 0.95 | 0.85 – 1.06 | 0.3263 |
Low volume (1.30– < 25 g/day) | 27/62 | 1.07 | 1.04 – 1.10 | 0.0001 | 1.08 | 1.05 – 1.12 | 0.0001 | 1.08 | 1.04 – 1.11 | 0.0001 |
Medium volume (25– < 45 g/day) | 18/20 | 1.06 | 1.02 – 1.11 | 0.0068 | 1.08 | 1.03 – 1.13 | 0.0023 | 1.07 | 1.02 – 1.12 | 0.0041 |
High volume (45– < 65 g/day) | 10/11 | 1.15 | 1.08 – 1.22 | 0.0001 | 1.17 | 1.09 – 1.25 | 0.0001 | 1.14 | 1.08 – 1.22 | 0.0001 |
Higher volume (65+ g/day) | 9/13 | 1.18 | 1.09 – 1.27 | 0.0001 | 1.20 | 1.11 – 1.29 | 0.0001 | 1.18 | 1.10 – 1.27 | 0.0001 |
Any drinking | 27/126 | 1.08 | 1.04 – 1.12 | 0.0039 | 1.10 | 1.02 – 1.18 | 0.0214 | 1.08 | 1.01 – 1.17 | 0.0364 |
Note: a N = Number of studies and n = Number of risk estimates. bWeighted using the inverse of variance of natural log–RR. cWeighted RR estimates adjusted for both former and occasional drinker biases. dWeighted RR estimates adjusted for between–study variation, both former and occasional drinker biases, US/non–US study and control for smoking status in individual studies