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. 2016 Nov 14;17:459. doi: 10.1186/s12859-016-1349-2

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — - Important properties for classification. The plot shows RF feature importance and AUC score for each property for the classification of each functional class (Pioneers (P), Settlers (S), positive Migrants (M+) and negative Migrants (M-)) versus Rest. This highlights the importance of structural TF classification (TFClass) and Pfam domains (PD) for correct classification of regulatory function. The other properties are DNA binding domain (DBD), number of DBDs (N_DBD), protein-protein interaction (PPI), number of PPIs (N_PPI), post-translational modifications, both in general (PTM) and as individual modifications (Ind_PTM), number of frequent zinc finger domains (N_ZFD) and number of positions for phosphorylation (N_PhS)