Table 12.
TESAOD application, obese subjects (N = 463 normal-weight, N = 66 obese)
| Lasso | Adaptive LASSO | Elastic Net | Iterated LASSO | Bootstrap-Enhanced LASSO-75 | Weighted Fusion | Logistic Regression, Coefficient (p-value) | |
|---|---|---|---|---|---|---|---|
| Adiponectin | −0.0101 | 0 | −0.0006 | 0 | 0 | −0.0853 | −0.3089 (0.018) |
| Alpha-1 Antitrypsin | 0 | 0 | 0 | 0 | 0 | −0.0320 | −0.0748 (0.573) |
| Alpha-Fetoprotein | −0.0256 | 0 | 0 | 0 | 0 | −0.0730 | 0.0009 (0.994) |
| Alpha-2 Macroglobulin | −0.0187 | 0 | −0.0065 | 0 | 0 | −0.1110 | −0.3163 (0.022) |
| Apolipoprotein A-1 | −0.2167 | −0.3546 | −0.1691 | −0.3127 | −0.2627 | −0.1011 | −0.1488 (0.260) |
| Apolipoprotein C-III | 0 | 0 | 0 | 0 | 0 | 0 | 0.1865 (0.121) |
| Apolipoprotein H | 0.0881 | 0.1642 | 0.0346 | 0 | 0.2160 | 0.1277 | 0.5315 (<0.001) |
| Beta-2 Microglobulin | 0 | 0 | 0 | 0 | 0 | 0.0417 | 0.3586 (0.005) |
| Brain Derived Neurotrophic Factor | 0 | 0 | 0 | 0 | 0 | 0 | 0.2784 (0.024) |
| Calcitonina | 0 | 0 | 0 | 0 | 0 | 0.0624 | 0.2469 (0.349) |
| Cancer Antigen 19-9 | −0.1216 | −0.1226 | −0.0633 | 0 | −0.3059 | −0.1439 | −0.1357 (0.269) |
| Cancer Antigen 125 | 0 | 0 | 0 | 0 | 0 | −0.0081 | 0.0942 (0.484) |
| Carcinoembryonic Antigen | −0.0516 | 0 | 0 | 0 | −0.1779 | −0.1107 | −0.1338 (0.301) |
| Soluble CD14 | −0.1020 | −0.1706 | −0.0488 | 0 | −0.2272 | −0.0965 | −0.0801 (0.544) |
| CD40 | 0 | 0 | 0 | 0 | 0 | −0.0167 | 0.2122 (0.109) |
| CD40Ligand | −0.0176 | 0 | 0 | 0 | 0 | −0.0808 | −0.0731 (0.580) |
| Club Cell Secretory Protein | 0 | 0 | 0 | 0 | 0 | −0.0705 | −0.1442 (0.263) |
| Complement 3 | 0.0899 | 0 | 0.0761 | 0 | 0 | 0.1306 | 0.5991 (<0.001) |
| C-Reactive Protein | 0.5213 | 0.7636 | 0.4765 | 0.6802 | 0.6052 | 0.2526 | 0.7864 (<0.001) |
| Creatine Kinase-MB | 0.0818 | 0.1652 | 0.0423 | 0 | 0.1442 | 0.0957 | 0.2967 (0.045) |
| Endothelin-1b | 0 | 0 | 0 | 0 | 0 | 0.0487 | 0.2000 (0.481) |
| Eotaxin | −0.0965 | −0.1557 | −0.0581 | 0 | −0.2893 | −0.1414 | −0.2317 (0.111) |
| Epidermal Growth Factor | 0 | 0 | 0 | 0 | 0 | 0.0190 | 0.1794 (0.198) |
| Epithelial-Derived Neutrophil-Activating Protein-78 | 0 | 0 | 0 | 0 | 0 | 0.0353 | 0.2525 (0.024) |
| Erythropoietina | 0 | 0 | 0 | 0 | 0 | −0.0174 | 0.0736 (0.780) |
| Extracellular Newly Identified RAGE-Binding Protein | 0 | 0 | 0 | 0 | 0 | 0.0092 | 0.0324 (0.803) |
| Fatty Acid Binding Protein | 0 | 0 | 0 | 0 | 0 | 0 | 0.3317 (0.029) |
| Ferritin | 0.0753 | 0 | 0.0469 | 0 | 0 | 0.0671 | 0.2900 (0.038) |
| Fibrinogen | 0 | 0 | 0 | 0 | 0 | 0.0168 | 0.1290 (0.320) |
| Fibroblast Growth Factor-Basicb | 0 | 0 | 0 | 0 | 0 | 0.0518 | 0.4799 (0.074) |
| Granulocyte Colony-Stimulating Factor | 0 | 0 | 0 | 0 | 0 | 0.0705 | 0.3130 (0.027) |
| Granulocyte-Macrophage Colony-Stimulating Factorb | 0 | 0 | 0 | 0 | 0 | 0.0086 | 0.2726 (0.430) |
| Growth Hormone | 0 | 0 | 0 | 0 | 0 | −0.0888 | −0.2576 (0.049) |
| Haptoglobin | 0 | 0 | 0 | 0 | 0 | 0.0107 | 0.2537 (0.027) |
| Immunoglobulin A | 0 | 0 | 0 | 0 | 0 | −0.0046 | 0.1143 (0.358) |
| Immunoglobulin E | 0 | 0 | 0 | 0 | 0 | 0 | −0.0469 (0.720) |
| Immunoglobulin M | −0.1014 | 0 | −0.0450 | 0 | 0 | −0.1120 | −0.1411 (0.278) |
| Intercellular Adhesion Molecule-1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.1826 (0.167) |
| Interferon-Gammaa | 0.0820 | 0.0300 | 0.0245 | 0 | 0.1199 | 0.1218 | 0.3461 (0.195) |
| Interleukin-1alphab | 0 | 0 | 0 | 0 | 0 | 0.0154 | 0.1322 (0.624) |
| Interleukin-1betaa | 0 | 0 | 0 | 0 | 0 | 0.0535 | 0.2558 (0.333) |
| Interleukin-1 Receptor Antagonist | 0 | −0.0844 | 0 | 0 | 0 | −0.0275 | 0.1284 (0.353) |
| Interleukin-3b | 0 | 0 | 0 | 0 | 0 | −0.0185 | 0.1956 (0.458) |
| Interleukin-4b | 0 | 0 | 0 | 0 | 0 | 0 | −0.0315 (0.906) |
| Interleukin-5a | 0 | 0 | 0 | 0 | 0 | −0.0203 | −0.0217 (0.934) |
| Interleukin-6a | 0 | 0 | 0 | 0 | 0 | −0.0069 | 0.4395 (0.098) |
| Interleukin-7b | 0.1132 | 0 | 0.0761 | 0.012 | 0 | 0.1345 | 0.6057 (0.023) |
| Interleukin-8 | −0.0407 | 0 | 0 | 0 | 0 | −0.0765 | −0.0588 (0.665) |
| Interleukin-10b | 0 | 0 | 0 | 0 | 0 | 0.0124 | 0.4472 (0.110) |
| Interleukin-12p40b | 0 | 0 | 0 | 0 | 0 | 0.0103 | 0.2217 (0.435) |
| Interleukin-13 | 0 | 0 | 0 | 0 | 0 | −0.0653 | −0.0841 (0.533) |
| Interleukin-15a | 0 | 0 | 0 | 0 | 0 | −0.0037 | 0.1434 (0.587) |
| Interleukin-16 | 0 | 0 | 0 | 0 | 0 | 0.0531 | 0.1822 (0.175) |
| Interleukin-18 | 0.1214 | 0.0653 | 0.0804 | 0.0774 | 0.2373 | 0.0870 | 0.3215 (0.015) |
| Leptin | 0.9186 | 1.1286 | 0.8548 | 1.2502 | 1.1505 | 0.3792 | 1.3928 (<0.001) |
| Lipoprotein (a) | 0 | 0 | 0 | 0 | 0 | 0 | −0.0010 (0.994) |
| Macrophage-Derived Chemokine | 0 | 0 | 0 | 0 | 0 | 0.0476 | 0.2533 (0.042) |
| Macrophage Inflammatory Protein-1alpha | 0 | 0 | 0 | 0 | 0 | 0.0531 | 0.2623 (0.057) |
| Macrophage Inflammatory Protein-1beta | 0 | 0 | 0 | 0 | 0 | 0.0241 | 0.2934 (0.022) |
| Matrix Metalloproteinase-2a | 0.1090 | 0 | 0.0776 | 0.0443 | 0.1443 | 0.1242 | 0.6992 (0.011) |
| Matrix Metalloproteinase-3 | 0 | 0 | 0 | 0 | 0 | −0.0308 | −0.0218 (0.868) |
| Matrix Metalloproteinase-9a | 0.0101 | 0.0832 | 0 | 0 | 0 | 0.0606 | 0.3084 (0.244) |
| Monocyte Chemotactic Protein-1 | 0.1628 | 0.1471 | 0.1269 | 0.1792 | 0.2546 | 0.1275 | 0.4521 (0.001) |
| Myeloperoxidase | 0 | −0.0542 | 0 | 0 | 0 | −0.0927 | −0.1054 (0.425) |
| Myoglobin | 0.0391 | 0 | 0.0316 | 0 | 0 | 0.0829 | 0.3239 (0.011) |
| Plasminogen Activator Inhibitor 1 | 0 | 0 | 0 | 0 | 0 | 0.0454 | 0.4603 (0.001) |
| Pregnancy-Associated Plasma Protein a | 0 | 0 | 0 | 0 | 0 | −0.0995 | −0.1306 (0.306) |
| Prostatic Acid Phosphatasea | 0 | 0 | 0 | 0 | 0 | −0.0477 | −0.0652 (0.805) |
| T-Cell Specific Protein RANTES | 0 | 0 | 0 | 0 | 0 | 0.0444 | 0.4370 (0.002) |
| Serum Amyloid P | 0 | 0 | 0.0019 | 0 | 0 | 0.0836 | 0.6526 (<0.001) |
| Serum Glutamic Oxaloacetic Transminase | 0.0340 | 0.0234 | 0 | 0 | 0 | 0.0851 | 0.0350 (0.791) |
| Sex Hormone Binding Globulin | −0.4768 | −0.6470 | −0.4499 | −0.7274 | −0.4767 | −0.2334 | −0.5552 (<0.001) |
| Stem Cell Factor | 0 | 0 | 0 | 0 | 0 | 0.0212 | 0.3146 (0.008) |
| Surfactant Protein D | −0.3136 | −0.4086 | −0.2351 | −0.3848 | −0.4663 | −0.2820 | −0.4833 (0.002) |
| Thrombopoietin | 0.0243 | 0 | 0.0147 | 0 | 0 | 0.0933 | 0.3849 (0.002) |
| Thyroid Stimulating Hormone | −0.0264 | −0.0034 | 0 | 0 | 0 | −0.0515 | −0.1010 (0.424) |
| Thyroxine Binding Globulin | 0 | 0 | 0 | 0 | 0 | 0 | 0.0722 (0.570) |
| Tissue Factorb | 0 | 0 | 0 | 0 | 0 | 0.0788 | 0.6627 (0.029) |
| Tissue Inhibitor of Metalloproteinase 1 | 0 | 0 | 0 | 0 | 0 | −0.0023 | 0.2617 (0.031) |
| Tumor Necrosis Factor-alpha | 0 | 0 | 0 | 0 | 0 | 0.0380 | 0.2958 (0.044) |
| Tumor Necrosis Factor-betab | 0.0165 | 0 | 0 | 0 | 0 | 0.0848 | 0.2309 (0.406) |
| Tumor Necrosis Factor RII | 0 | 0 | 0 | 0 | 0 | 0.0287 | 0.3291 (0.011) |
| Vascular Cell Adhesion Molecule-1 | 0 | 0.1194 | 0 | 0 | 0 | 0.0828 | 0.2680 (0.043) |
| Vascular Endothelial Growth Factor | 0 | 0 | 0 | 0 | 0 | 0 | 0.3250 (0.015) |
| von Willebrand Factor | 0.1980 | 0.0683 | 0.1737 | 0.2571 | 0.2694 | 0.1364 | 0.4185 (<0.001) |
| YKL-40 | 0.1095 | 0.0847 | 0.0733 | 0.0314 | 0.1979 | 0.1151 | 0.3671 (0.005) |
aCategorized at median; bCategorized at detection limit