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Prodrugs targeting the SH2 domain of STAT6 inhibit the expression of CCL26 mRNA. Beas-2B cells plated at 4 × 105 cells/well and incubated overnight in complete media, serum starved for 2 h, pretreated with drug for 2 h, stimulated with IL-13 overnight in serum free media, and total CCL26 mRNA was quantitated on cell lysates.
