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. Author manuscript; available in PMC: 2016 Nov 15.
Published in final edited form as: J Med Chem. 2015 Nov 9;58(22):8970–8984. doi: 10.1021/acs.jmedchem.5b01321

Table 4.

Effect of Constrained pTyr Surrogates on Affinity for Phosphodipeptide R-Tle-Pro-N(Ph)(4-I-Phe) for STAT6

graphic file with name nihms828572t5.jpg

R IC50(µM)
18a pCinn
βMpCinn
0.044 ± 0.016
19a graphic file with name nihms828572t6.jpg 0.028 ± 0.006
20 p-Indole 0.14 ± 0.06