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. 2015 Dec 11;18(6):913–919. doi: 10.4103/1008-682X.167714

Figure 5.

Figure 5

The expression of p-Akt and p-ERK1/2 in LNCaP (a) and PC3 (b) cells in mono-culture or in co-culture with fibroblasts or HPF in co-culture transwells. Finasteride repressed the expression of p-Akt and p-ERK1/2 in mono-culture of LNCaP (PC3) cells. However, when LNCaP (PC3) cells were grown with fibroblasts or HPF in co-culture transwell, Finasteride upregulated the expression of p-Akt and p-ERK1/2 in cancer cells. When c-Jun in fibroblasts was knocked out, the pro-proliferative effect of finasteride for LNCaP (PC3) cells was attenuated, especially for p-ERK1/2 in the same co-culture transwells.