Table 2.
Baseline ECG parameters in WT and Kcna1-null mice
| WT (n = 10) | KO (n = 12) | P | |
|---|---|---|---|
| Age, months | 4.0 ± 0.3 | 4.1 ± 0.3 | 0.68 |
| Heart mass, ga | 160 ± 11 | 173 ± 12 | 0.48 |
| Heart:body ratio, mg/ga | 4.8 ± 0.2 | 5.3 ± 0.3 | 0.23 |
| PQ, ms | 27.0 ± 0.6 | 27.0 ± 1.2 | 1.00 |
| QRS, ms | 7.8 ± 0.4 | 6.9 ± 0.2 | 0.04 |
| QT, ms | 34.0 ± 1.6 | 34.8 ± 1.3 | 0.69 |
| QTc, ms | 57.2 ± 1.6 | 57.6 ± 1.7 | 0.88 |
| RR, ms | 96.8 ± 2.1 | 98.3 ± 2.6 | 0.67 |
| SCL, ms | 96.7 ± 2.0 | 98.3 ± 2.5 | 0.65 |
| AV, ms | 33.4 ± 0.9 | 33.8 ± 0.9 | 0.73 |
| SNRT, ms | 122.0 ± 6.2 | 125.5 ± 8.4 | 0.75 |
| RA ERP, ms | 28.7 ± 2.0 | 31.7 ± 2.1 | 0.34 |
| AV ERP, ms | 40.1 ± 1.9 | 41.5 ± 3.2 | 0.75 |
Data are expressed as mean ± SEM. Student’s t test used to compare intragroup differences. P values between WT and KO mice are shown SCL sinus cycle length, AV atria-to-ventricle conduction time, SNRT sinus node recovery time, RA ERP right atrial effective refractory period, AV ERP atrioventricular node effective refractory period
a
Data derived from 9 KO and 6 WT animals