Table 4.

Adverse events associated with bevacizumab.

Adverse events
Headache	Rhinitis	Rectal hemorrhage
Epistaxis	Taste alteration	Lacrimation disorder
Hypertension	Dry skin
Proteinuria	Exfoliative dermatitis
Warnings and precautions
Nongastrointestinal fistula formation
Arterial thromboembolic events (myocardial infarction, cerebrovascular accident)
Hypertension (crisis or encephalopathy)
Reversible posterior leukoencephalopathy syndrome
Nephrotic syndrome
Arterial thrombosis
Infusion reactions
Black box warnings
Gastrointestinal perforation
Surgical and wound-healing complications
Hemorrhage

Those that have increased at least 2-fold in bevacizumab-treated patients over controls in the trials listed in Table 2 and included in the FDA-approved bevacizumab package insert. The most common or concerning are in bold.