Table 5.

National Cancer Institute common toxicity criteria of adverse events³⁴.

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4
Hypertension	Prehypertension (systolic BP 120–139 mm Hg or diastolic BP 80–89 mm Hg)	Stage 1 hypertension (systolic BP 140–159 mm Hg or diastolic BP 90–99 mm Hg); medical intervention indicated; recurrent or persistent (≥24 h); symptomatic increase by >20 mm Hg (diastolic) or to >140/90 mm Hg if previously WNL; monotherapy indicated.	Stage 2 hypertension (systolic BP ≥160 mm Hg or diastolic BP ≥100 mm Hg); medical intervention indicated; more than one drug or more intensive therapy than previously used indicated	Life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated
Proteinuria	Urinary protein <1.0 g/24 h; UPCR <1	Urinary protein 1.0–3.5 g/24 h; UPCR 1–3.5	Urinary protein >3.5 g/24 h; UPCR >3.5	Nephrotic syndrome

BP=blood pressure; WNL=within normal limits; UPCR=urine protein to creatinine ratio.