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. 2016 Nov 14;213(12):2553–2565. doi: 10.1084/jem.20160600

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© 2016 Wu et al.

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Figure 4. — LCs at steady state are marked by Mafb-driven lineage tracing but express Zbtb46. (A) Migrated LCs in the inguinal LN of MafB-mCherry-Cre × R26-stop-YFP × Zbtb46-GFP mice are displayed for expression of Zbtb46-GFP and lineage-tracing marker YFP in a two-color histogram (top), and dermal DC populations in the same tissue identified by Zbtb46-GFP and CD24 are displayed for expression of YFP (bottom). Shown is one representative sample (n ≥ 4 animals over at least two independent experiments). (B) LCs in the epidermis of wild-type or MafB-mCherry-Cre × R26-stop-YFP × Zbtb46-GFP (mCherry × YFP × GFP) mice, gated as in Fig. S2 A, are compared for expression of Zbtb46-GFP and YFP in two-color histograms. Shown is one representative sample per group (n ≥ 2 animals per group over at least two independent experiments). (A and B) Numbers indicate percentage of cells within the indicated gate. (C) LCs in the epidermis of wild-type (Zbtb46^+/+) or Zbtb46-deficient (Zbtb46^gfp/gfp) mice, gated as in Fig. S2 B, are compared for expression of Zbtb46-GFP and Zbtb46 protein in one-color histograms. Shown is one representative sample per group (n = 3 animals per group over two independent experiments).