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. 2016 Nov 14;213(12):2567–2574. doi: 10.1084/jem.20160723

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© 2016 Suzuki et al.

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Figure 1. — Diurnal oscillation of lymphocyte numbers in circulation and LNs. (A–D) Numbers of B cells and CD4⁺ T cells in blood (A), lymph (B), and peripheral LNs (the sum of inguinal, axillary, and brachial LNs; C), and the noradrenaline content in peripheral LNs (D) of WT mice at the indicated ZTs. Data in A–D are representative of two experiments and shown as the mean ± SD of four mice. (E–H) Noradrenaline levels in peripheral LNs (E) and numbers of B cells and CD4⁺ T cells in blood (F), lymph (G), and peripheral LNs (H) of vehicle- and 6-OHDA–treated mice at the indicated ZTs. (I–K) Numbers of B cells and CD4⁺ T cells in blood (I), lymph (J), and peripheral LNs (K) of WT (Adrb2^+/+ or Adrb2^+/− littermates) and Adrb2^−/− mice at the indicated ZTs. Data are pooled from two (E and K) or three (F–J) experiments. Each symbol represents an individual mouse (at least six mice per group) and bars indicate means. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant. P-values were obtained by one-way ANOVA with Dunnett’s post-hoc test in comparison with the trough (A–D) or two-way ANOVA with Tukey’s post-hoc test (E–K).