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. 2016 Nov 14;213(12):2745–2758. doi: 10.1084/jem.20160726

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© 2016 Nabekura and Lanier

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Figure 3. — IL-12 is required for the optimal differentiation of memory NK cells and cytokine-activated NK cells. NKp46-CreERT2 Tg mice with homozygous Rosa26-YFP alleles were treated daily with tamoxifen on days 0–4 and infected with MCMV on day 0. Mice were injected with 200 µg control Ig or anti–IL-12 neutralizing mAb on the day before infection and on day 3 and 6 p.i. The percentages of YFP⁺Ly49H⁺KLRG1^high memory NK cells and cytokine-activated YFP⁺Ly49H⁻KLRG1^high NK cells in the spleens on day 26 p.i. are shown. Data are pooled from two experiments (n = 4–5 in each group). *, P < 0.01; **, P < 0.005 versus control Ig. P-values were calculated by a Student’s t test. Error bars show SEM.