Table 1. Biomarkers in peripheral tissues.

	mtHtt staining	4-HNE staining
Muscle
WT TAT	80.8 ± 2.0	45.1 ± 2.8
WT P110	94.8 ± 0.5
R6/2 TAT	143.3 ± 0.4a	91.8 ± 2.5b
R6/2 P110	57.1 ± 0.6c
Skin
WT TAT	96.4 ± 4.2	95.3 ± 2.8
WT P110	89.4 ± 3.3
R6/2 TAT	141 ± 5.0d	148.6 ± 7.0e
R6/2 P110	85.7 ± 3.5f

Quantification of images of mtHtt and 4-HNE staining in muscle and skin. Images of the respective staining were obtained from three mice/group, and 16 areas of each section were analyzed. 58 areas of each section were analyzed for mtHtt staining in muscle. Data are presented as mean ± SEM.

^aP = 0.038 (WT TAT vs. R6/2 TAT)

^bP = 0.0026 (WT TAT vs. R6/2 TAT)

^cP = 0.027 (R6/2 TAT vs. R6/2 P110)

^dP = 0.019 (WT TAT vs. R6/2 TAT)

^eP = 0.018 (WT TAT vs. R6/2 TAT)

^fP = 0.015 (R6/2 TAT vs. R6/2 P110)