Table 1. Coverage across the cohort over PKD1, PKD2 and the whole genome.

	Average	95% confidence interval	Range
PKD1
Mean coverage	29.8	28.7–30.9	24.8–36.8
% bases covered >5 ×	99.4	99.1–99.7	97.8–100
% bases covered >10 ×	98.9	98.5–99.3	96.5–100
% bases covered >15 ×	97.3	96.7–97.9	93.4–99.9
% bases covered >20 ×	92.8	91.5–94.1	84.8–97.7
PKD2
Mean coverage	31.1	30.1–32.1	26.1–36.8
% bases covered >5 ×	99.9	99.9–99.9	99.6–100
% bases covered >10 ×	99.5	99.2–99.8	97.5–100
% bases covered >15 ×	98.5	97.9–99.1	94.7–100
% bases covered >20 ×	94.9	93.6–96.2	87.6–98.5
Whole genome
Mean coverage	31.9	31.0–32.8	28.4–36.1
% bases covered >5 ×	97.2	97.0–97.4	96.4–97.9
% bases covered >10 ×	96.1	95.9–96.3	94.9–97.0
% bases covered >15 ×	92.9	92.3–93.5	89.4–95.5
% bases covered >20 ×	85.0	83.6–86.4	77.7–91.6

Mean coverage and the percentage of bases covered to a minimum depth of 5 times, 10 times, 15 times and 20 times across the protein coding exons of PKD1, PKD2 and the whole genome. To assess coverage, PCR duplicates were filtered, and reads with MQ≥0 were used for the whole genome, and reads with MQ≥20 for PKD1 and PKD2.