Table 3. Manchester scoring system to identify likelihood of a BRCA1/2 mutation.
Case of relevant cancer and age at diagnosis | BRCA1 | BRCA2 |
---|---|---|
FBC <30 | 6 | 5 |
FBC 30–39 | 4 | 4 |
FBC 40–49 | 3 | 3 |
FBC 50–59 | 2 | 2 |
FBC >59 | 1 | 1 |
MBC <60 | 5 if BRCA2 tested | 8 |
MBC >59 | 5 if BRCA2 tested | 5 |
Ca ovary <59 | 8 | 5 if BRCA1 tested |
Ca ovary >60 | 5 | 5 if BRCA1 tested |
Ca pancreas | 0 | 1 |
Ca prostate <60 | 0 | 2 |
Ca prostate >59 | 0 | 1 |
Each cancer in a direct lineage is scored including contralateral breast cancers. The highest lineage score is used.