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. 2016 Jun 8;24(11):1591–1597. doi: 10.1038/ejhg.2016.57

Table 3. Manchester scoring system to identify likelihood of a BRCA1/2 mutation.

Case of relevant cancer and age at diagnosis BRCA1 BRCA2
FBC <30 6 5
FBC 30–39 4 4
FBC 40–49 3 3
FBC 50–59 2 2
FBC >59 1 1
MBC <60 5 if BRCA2 tested 8
MBC >59 5 if BRCA2 tested 5
Ca ovary <59 8 5 if BRCA1 tested
Ca ovary >60 5 5 if BRCA1 tested
Ca pancreas 0 1
Ca prostate <60 0 2
Ca prostate >59 0 1

Each cancer in a direct lineage is scored including contralateral breast cancers. The highest lineage score is used.