Table 3. Frequencies of inferred four-locus haplotypes for mdr1-1Δ-bearing chromosomes among affected breeds.
| Haplotypes | Collie U.K. (n = 123) | Collie U.S. (n = 177) | Australian Shepherd (n = 48) | Miniature Australian Shepherd (n = 29) | English Shepherd (n = 13) | McNab (n = 12) | Old English Sheepdog (n = 10) | Shetland Sheepdog (n = 32) | Longhaired Whippet (n = 74) | Silken Windhound (n = 30) |
|---|---|---|---|---|---|---|---|---|---|---|
| I 239 mdr1 173 259 153 | 0.236 | 0.542 | 0.354 | 0.759 | 0.308 | 0.100 | 0.063 | |||
| 239 mdr1 173 259 157 | 0.041 | 0.692 | ||||||||
| 239 mdr1 173 259 155 | 0.577 | |||||||||
| 239 mdr1 173 259 159 | 0.600 | |||||||||
| 243 mdr1 173 255 153 | 0.200 | |||||||||
| 245 mdr1 173 251 153 | 0.147 | 0.125 | ||||||||
| 247 mdr1 173 255 159 | 0.100 | |||||||||
| II 249 mdr1 173 259 153 | 0.106 | 0.181 | 0.521 | 0.207 | 0.781 | 0.986 | 0.733 | |||
| 249 mdr1 173 259 157 | 0.017 | 0.042 | 1.000 | |||||||
| 249 mdr1 175 259 161 | 0.233 | |||||||||
| Other | 0.040 | 0.113 | 0.083 | 0.034 | 0.031 | 0.014 | 0.034 |
n, number of mutant chromosomes. Haplotypes I and II are bold, as are the most frequent haplotypes for each breed. The loci order is C14.866-mdr1-1Δ-REN103E18-REN144I15-GO1506. Table 9, which is published as supporting information on the PNAS web site, provides a full list of mutant haplotypes.