Table 3.
Age adjusted incidence rate ratios and 95% confidence intervals for association of community acquired pneumonia (multiple events of pneumonia during observation period) with proton pump inhibitors (PPI) according to three different definitions of community acquired pneumonia (self controlled case series analysis)
| Period | Pneumonia definition | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Broad primary care definition (n=48 451) | Narrow primary care definition (n=4461) | Hospital and mortality records based definition (in HES-ONS linked patients) (n=5582) | |||||||||
| No of events | Person years | IRR (95% CI) | No of events | Person years | IRR (95% CI) | No of events | Person years | IRR (95% CI) | |||
| Baseline unexposed period | 74 121 | 531 201 | 1.0 | 3083 | 46 254.4 | 1.0 | 7212 | 41 172.2 | 1.0 | ||
| Pre-exposure period (30 days before first PPI prescription) | 2698 | 9099.32 | 1.92 (1.84 to 2.00) | 212 | 798.275 | 3.72 (3.23 to 4.30) | 642 | 815.828 | 4.16 (3.82 to 4.53) | ||
| 30 days exposure period (30 days after first PPI prescription) | 1679 | 9067.54 | 1.19 (1.14 to 1.25) | 151 | 791.452 | 2.70 (2.29 to 3.19) | 393 | 802.223 | 2.69 (2.42 to 2.98) | ||
| Remaining exposure period | 17 557 | 83 720.3 | 1.49 (1.46 to1.52) | 1430 | 9262.69 | 3.18 (2.93 to 2.46) | 3134 | 8824.76 | 2.44 (2.31 to 2.58) | ||
All comparisons against baseline pneumonia incidence rate in unexposed periods.
HES=Hospital Episode Statistics; IRR=incidence rate ratio; ONS=Office for National Statistics.