FIG 8.
Convallatoxin is effective at limiting dissemination of clinical strains. (A to D) HFFs infected with the clinical strains BI-4 (A), BI-6 (B), CH13 (C), and CH19 (D) were treated with convallatoxin at various concentrations for up to 7 days. The number of plaques and viral DNA copies were analyzed and determined, setting DMSO-treated cells as 100%. (E) MRC5 cells treated with various doses of convallatoxin (7 days) were radiolabeled with [35S]Met. The cell lysates were directly subjected to liquid scintillation, and the normalized values represent averages of 3 replicates, with DMSO-treated cells set as 100%. The error bars are standard errors.