. 2016 Nov 14;90(23):10936–10944. doi: 10.1128/JVI.01646-16

TABLE 1.

Infectivity, morbidity, and mortality observed in mice infected by HPAI or LPAI H7N8 virus

Virus	Subtype	Pathogenicity^a	HA cleavage site sequence	Mean wt loss (%)^b	Mean lung titer (log₁₀ EID₅₀/ml) ± SD at day^c:		MID₅₀^d	LD₅₀^d
Virus	Subtype	Pathogenicity^a	HA cleavage site sequence	Mean wt loss (%)^b	3	6	MID₅₀^d	LD₅₀^d
A/Turkey/Indiana/1403/2016	H7N8	HPAI	PENPKKRKTR/G	24.9	6.41 ± 0.29	5.83 ± 0.38	1.0	3.4
A/Turkey/Indiana/1573-02/2016	H7N8	LPAI	PENP…..KTR/G	14.1	3.50	5.38 ± 0.18 (2/3)	3.3	>6.0

The pathogenicity phenotype in chickens was determined using the intravenous pathogenicity index (IVPI) (37).

Mean maximum weight loss (%) following i.n. inoculation with 10^6.0 EID₅₀ of virus (five mice per group).

Mean viral titers in lungs following i.n. inoculation with 10^6.0 EID₅₀ of virus on day 3 or 6 p.i. among mice with positive virus detection. Titers are reflective of 3 mice per group unless otherwise specified in parentheses.

MID₅₀ and LD₅₀ are expressed as the log₁₀ EID₅₀ required to give a value of 1 for MID₅₀ or LD₅₀.