TABLE 2.
Clinical signs, viral replication, and transmission of HPAI and LPAI H7N8 virus among ferrets
| Virus | Result (mean maximum for indicated value or no. of animals with result/no. inoculated or exposed) for indicated parameter in ferrets exposed by: |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Inoculation |
Direct contact |
||||||||
| Wt loss (%)a | Temp increase (°C)b | Lethargy score (RII)c | Lethalityd | Respiratory signs | Gastrointestinal signs | Viral titer ± SD (log10 EID50/ml) in nasal wash samples | Virus detected | Seroconversion | |
| A/Turkey/Indiana/1403/2016 (HPAI) | 15.6 | 1.7 | 1.6 | 1/3 (10) | 0/3 | 1/3 | 5.17 ± 0.95 | 0/3 | 0/3 |
| A/Turkey/Indiana/1573-02/2016 (LPAI) | 1.2 | 1.1 | 1.0 | 0/3 | 0/3 | 0/3 | 5.33 ± 0.88 | 1/3 | 1/3 |
a
Mean maximum weight loss (%) during first 10 days p.i.
b
Mean maximum temperature increase over baseline during first 10 days p.i.
c
RII, relative inactivity index (38) during 12 days p.i.
d
Number of animals that succumbed to infection/total number of animals. The day p.i. that one animal was euthanized due to excessive weight loss is shown in parentheses.