TABLE 2.

Sequence and structural similarity of capsid proteins of selected picornaviruses

Family and genus	Virus	Sequence and structural similarity (% or RMSD)a
		AiV-1	TMEV	ERAV	SVV-1	PV-1	HRV14	EV71	CVA16	HAV	HPeV-1	CrPV
Picornaviridae
Kobuvirus	AiV-1		1.9	2.0	1.8	1.8	1.8	1.8	1.8	2.1	2.2	2.6
Cardiovirus	TMEV	28		1.9	1.4	1.5	1.5	1.7	1.6	2.0	2.1	2.8
Aphthovirus	ERAV	25	33		1.9	1.8	1.7	1.7	1.7	2.4	2.6	3.0
Senecavirus	SVV-1	28	38	31		2.3	1.7	1.8	1.7	2.0	2.2	3.2
Enterovirus	PV-1	24	29	24	29		1.0	1.1	1.0	2.1	2.1	2.6
	HRV14	25	26	25	28	49		1.1	1.2	2.1	2.1	2.8
	EV71	26	30	23	29	44	44		0.5	2.1	2.2	2.5
	CVA16	25	30	22	30	47	44	79		2.1	2.2	2.6
Hepatovirus	HAV	17	21	18	20	18	19	17	15		2.1	2.6
Parechovirus	HPeV-1	20	20	18	18	17	17	17	15	18		2.7
Dicistroviridae
Cripavirus	CrPV	16	14	17	11	13	11	14	14	16	17

^aThe top right portion of the table presents the root mean square deviations (Å) of superimposed Cα atoms of the respective 3D structures. The distance cutoff for inclusion of residues in the calculation was 3.8 Å. Capsid protein protomers corresponding to icosahedral asymmetric units consisting of subunits VP1 to VP4 were used in the comparisons. The program Coot was used for superposition of the molecules (47). The bottom left portion of the table presents the percent identities between respective virus coat protein sequences. Gaps were ignored in the calculations.