FIG 7.
The amino-terminal domain enables CWD conversion of human rPrPc. (A) Prion-positive or prion-negative brain homogenate from white-tailed deer was added to truncated or full-length human rPrPc. Experiments for both were performed under the same conditions, which are described in Materials and Methods. (B) Prion-positive or prion-negative brain homogenate from white-tailed deer was added to truncated or full-length bank vole rPrPc. Scatterplots represent raw data. *, P < 0.05 (WMW test), for the difference between the CWD susceptibilities of full-length and truncated substrates.