FIG 6.

Growth-enhanced mutants are less dependent on SR-BI for infection. Huh7.5 cells were preincubated with a dilution series of anti-SR-BI for 1 h at 37°C and then infected with parental and mutant viruses. Infection was quantified 72 h later by FFA. In each panel, the dose-response curve for a single mutant virus is displayed with the same control dose-response curve as that for parental virus. The mutants are displayed in the panels as Q412R (A), T416R (B), S449P (C), T563V (D), A579R (E), L619T (F), V626S (G), K632T (H), and L644I (I). Error bars represent SEM. The results are averages from three independent experiments performed in quadruplicate.