TABLE 3.
Number of genotype 2 sequences in the ViPR database bearing each amino acid at the site of adaptive mutationa
| Amino acid | No. of genotype 2 sequences in virus: |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Q412R | T416R | S449P | T563V | A579R | L619T | V626S | K632T | L644I | |
| Ala (A) | 4 | 33 | 1,338 | 1 | 252 | ||||
| Arg (R) | 31 | 1 | 9 | 1 | |||||
| Asn (N) | 136 | 82 | 1 | ||||||
| Asp (D) | 13 | 2 | 212 | ||||||
| Cys (C) | 1 | ||||||||
| Gln (Q) | 3,986 | 1 | 1 | 4 | |||||
| Glu (E) | 181 | 110 | 2 | 1 | |||||
| Gly (G) | 9 | 3 | 11 | 1 | |||||
| His (H) | 36 | 1 | 3 | ||||||
| Ile (I) | 2 | 1 | 7 | 1 | |||||
| Leu (L) | 4 | 117 | 469 | 9 | 417 | ||||
| Lys (K) | 5 | 8 | 4 | 460 | |||||
| Met (M) | 12 | 1 | 6 | ||||||
| Phe (F) | 1 | 2 | 41 | ||||||
| Pro (P) | 45 | 2 | 3 | ||||||
| Ser (S) | 231 | 803 | 1,868 | 220 | 1 | ||||
| Thr (T) | 28 | 3,211 | 5 | 528 | 12 | 1 | |||
| Trp (W) | 14 | ||||||||
| Tyr (Y) | |||||||||
| Val (V) | 1 | 3 | 444 | 1 | |||||
| Total | 4,737 | 4,253 | 3,556 | 531 | 512 | 469 | 465 | 466 | 466 |
a
All HCV genotype 2 E2 amino acid sequences in the ViPR database were aligned, and the number of sequences containing each residue at the sites of our adaptive mutations was determined.