TABLE 1.
Distributions of capsids in cellular compartments
| Cell typea | Virus | % of capsids |
||
|---|---|---|---|---|
| Extranuclearb | Perinuclearc | Intranucleard | ||
| UL34WT-expressing cells | HSV-1(F) | 43.35 | 3.19 | 53.46 |
| UL34-null | 42.66 | 1.21 | 56.13 | |
| Q163A-expressing cells | HSV-1(F) | 28.76 | 0.67 | 70.56 |
| UL34-null | 7.18 | 0 | 92.81 | |
a
Ten cell sections for each condition were used for quantitation.
b
Extranuclear capsids are defined as DNA- or non-DNA-containing capsids located within the cytoplasm or the extracellular space.
c
Perinuclear capsids are defined as enveloped capsids between the INM and the ONM.
d
Intranuclear capsids are defined as DNA- or non-DNA-containing capsids within the nucleus.