TABLE 2.
Glycan-V3 antibody light chain genetic characteristicsa
| MAb | IGLV | IGLJ | CDRH3 length (aa) | CDRL3 amino acid sequence | V gene nt mutation frequency (%) | Indel(s) |
|---|---|---|---|---|---|---|
| N170-VRC21.01 | λ6-57*01 | λ3*02 | 10 | QSYDSNYYWV | 24/273 (9) | |
| N170-VRC21.02 | 10 | QSYDDTYFWV | 26/273 (10) | |||
| N170-VRC22.01 | κ1-17*01 | κ1*01 | 9 | LQYNTFPRT | 16/264 (6) | |
| N170-VRC28.01 | κ2-28*01 | κ1*01 | 9 | MQGIDTPRT | 50/279 (18) | |
| N170-VRC29.01 | κ3-20*01 | κ1*01 | 9 | HQYDRSPRT | 15/267 (6) | |
| N170-VRC29.02 | 9 | QQFDFSPRT | 23/267 (9) | |||
| N170-VRC29.03 | 9 | QQYDFSPRT | 24/267 (9) | |||
| N170-VRC29.04 | 9 | EQYDVSPRT | 22/267 (8) | |||
| PGT121 | λ3-21*02 | λ3*02 | 12 | HIWDSRVPTKWV | 41/237 (17) | 21-nt FR1 del; 9-nt FR3 ins |
| PGT128 | λ3-8*01 | λ2 or 3 | 10 | GSLVGNWDVI | 20/270 (7) | 15-nt CDR1 del |
| PGT135 | λ3-15*01 | λ1*01 | 9 | QQYEEWPRT | 35/204 (17) | |
| PCDN38A | κ3-20*01 | κ1*01 | 8 | QQCGSSPT | n.a. (11) |
a
Indel, insertion or deletion; ins, insertion; del, deletion; nt, nucleotide; aa, amino acids; FR, framework region; CDR, complementarity-determining region; n.a., data not published.