TABLE 4.
Transmission of classical-BSE and BSE-derived inocula in Bv109M mice
| Inoculum | 1st passage |
2nd passage |
||
|---|---|---|---|---|
| Mean survival timea | PrPres type | Mean survival timea | PrPres type | |
| Ca-BSE 1 | >1,044 (0/6) | ND | 92 ± 8 (15/15) | 17 |
| Sh-BSE-3 | 571 ± 171 (7/14) | 18 | 63 ± 3 (7/7) | 18 |
| Sh-BSE-4 | 695 ± 110 (9/11) | 17 | 80 ± 5 (8/8) | 17 |
| 18 | 65 ± 4 (8/8) | 18 | ||
| Sh-BSE-5 | 449 ± 121 (7/13) | 17 | 79 ± 7 (7/7) | 17 |
| 18 | 64 ± 2 (7/7) | 18 | ||
| Sh-BSE-6 | 631 ± 221 (3/11) | 17 | 81 ± 3 (4/4) | 17 |
| vCJD-UK | 760 ± 107 (7/17) | 17 | 83 ± 9 (8/8) | 17 |
| 18 | 69 ± 11 (9/9) | 18 | ||
a
Survival time is indicated as mean number of days postinfection ± SD of all the mice scored positive for PrPres. n, number of diseased PrPres-positive animals; n0, number of inoculated animals. ND, no data.