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. 2016 Nov 14;90(23):10459–10471. doi: 10.1128/JVI.01701-16

FIG 4.

FIG 4

Interspecies analysis using ClustalW alignment of the VP1 capsid proteins of RV-A34 and RV-C3 to a sample of five RV-A and RV-C genotypes from each species. The shaded areas indicate amino acids that are fully conserved between the 12 RV-A and RV-C genotypes analyzed. The 10 boxed regions indicate motifs conserved across 101 RV-A and RV-B prototype strains (18). The red boxes indicate regions that underwent RV-C species-specific amino acid substitutions (24), which are highlighted in red. The RV-C and RV-A immunodominant regions C1, C2, C3, and C4 and A1 and A2 are indicated above and below each RV-C3 and RV-A34 sequence, respectively.