Fig. 1.

PU-H71 sensitizes human cancer cells to heavy ion irradiation. HeLa-SQ5, H1299, A549 and HFL-III cells were pretreated with 1 µM PU-H71 or DMSO for 24 h, and irradiated with carbon ions (LET; ~50 keV/µm) or X rays. The ability of PU-H71 to radiosensitize human tumor and normal cells was determined by colony formation assay. Colonies containing more than 50 cells were counted as surviving cells. Data represent mean ± SEM for two or three determinations. * indicates p < 0.05.