Fig. 3.

(a) Thermal factor profiles for the liganded (red) and the unliganded form (black). Some of the differences shown are presumably due to the different resolutions and different crystal packing. The most dramatic differences, however, are in the vicinity of the duplicated helix. The orange and blue bars indicate the duplicated sequence. (b) Comparison of the residue-accessible surface-area profiles of the liganded (red) and unliganded (black) structures. The orange and blue bars indicate the duplicated sequence. For parts of the protein away from the region of duplication, the two profiles are essentially identical. Within the region of duplication there are major differences highlighted in Inset (see text for discussion).