Table 1.
Medical characteristics and treatment options.
| Medical Symptom | Age of Onset | Treatment Options |
|---|---|---|
| hypotonia and feeding difficulties | 0–9 months | feeding assistance, nasogastric tubes |
| hyperphagia | 4.5–8 years | behavioral therapy |
| short stature | puberty | GH therapy, allows patients to reach full adult height |
| hypoplastic genitalia | birth | hormonal replacement therapy |
| dysmorphic features | birth | none |
| sleep-disordered breathing and daytime hypersomnolence | childhood to adolescence (Nixon and Brouillette) | adenotonsillectomy, nocturnal ventilation, weight control, and behavioral interventions |
| cognitive disability | childhood | none |
| skin picking and obsessive behavior | 5 years | behavioral therapy |
| oppositional behavior and tantrums | 5 years | behavioral therapy and psychiatric drugs |