Table 2.
Mouse and zebrafish PWS-related genes.
| Human | Mouse | % aa | Zebrafish | % aa | Chr. |
|---|---|---|---|---|---|
| FRAT1; Chr10 * | Peg12 | 70 | gbp + | 63 | 16 |
| MKRN3 | Mkrn3 | 63 | mkrn1 | 48 | 4 |
| MAGEL2 | Magel2 | 53 | ndnl2 &,+ | 48 | 23 |
| NDN | Ndn | 82 | ndnl2 &,+ | 40 | 23 |
| NPAP1 | Pom121; Chr5 * | 28 | pom121 + | 24 | 10 |
| SNRPN | Snrpn | 100 | snrpb | 93 | 6 |
| SNORD107 | Snord 107 | - | |||
| SNORD64 | Snord 64 | - | |||
| SNORD116@27 | Snord116@27 | - | |||
| SNORD115@41 | Snord115@130 | - | |||
| SNORD108 | - | - | |||
| SNORD109A | - | - | |||
| SNORD109B | - | - |
% aa, percent amino acid identity to human; Chr., Chromosome; *, ortholog is located outside the PWS-associated region; -, no identified orthologous gene; &, ndnl2 is orthologous to both MAGEL2 and NDN; +, zebrafish mutant has been generated; @, copy numbers according to [11].