Table 7. Diagnostic efficacy of each of the diagnostic modalities for discriminating between EC and LGA, including the preoperative biopsy criterion, CE-WLI criterion, VS classification criterion and complex pattern criterion.

	Preoperative biopsy	CE-WLI	VS classification	Complex pattern
Sensitivity (95 %CI)	0.468 (0.353 – 0.585)	0.709 (0.596 – 0.806)	0.848 (0.75 – 0.919)	0.861 (0.765 – 0.928)
Specificity (95 %CI)	0.857 (0.637 – 0.97)	0.571 (0.34 – 0.782)	0.476 (0.257 – 0.702)	0.389 (0.146 – 0.57)
PPV (95 %CI)	0.923 (0.791 – 0.984)	0.862 (0.753 – 0.935)	0.859 (0.762 – 0.927)	0.829 (0.73 – 0.903)
NPV (95 %CI)	0.305 (0.192 – 0.439)	0.343 (0.191 – 0.522)	0.455 (0.244 – 0.678)	0.389 (0.173 – 0.643)
LR +  (95 %CI)	3.273 (1.118 – 9.584)	1.654 (0.99 – 2.765)	1.619 (1.066 – 2.46)	1.291 (0.942 – 1.769)
LR –  (95 %CI)	0.621 (0.473 – 0.816)	0.509 (0.307 – 0.845)	0.319 (0.16 – 0.634)	0.418 (0.185 – 0.945)
Diagnostic accuracy (95 %CI)	0.551 (0.447 – 0.652)	0.68 (0.579 – 0.77)	0.77 (0.675 – 0.848)	0.75 (0.653 – 0.831)

CE-WLI, conventional endoscopy with white light; VS, vessel plus surface; PPV, positive predictive value; NPV, negative predictive value; LR + , likelihood ratio of a positive test; LR – , likelihood ratio of a negative test; 95 %CI, 95 % confidence interval.