Table 1. Proposed phenotypic LSC markers.

A compilation of proposed phenotypic LSC-specific markers in AML, their alternate name(s), known biological function(s), and some of the cell type(s) they are known to be positive on.

	Alternate name(s)	Function(s)	Cell Type(s)
CD25	IL-2Rα	T cell proliferation, inflammatory responses	T cells, B cells
CD26	Dipeptidyl peptidase-4 (DPP4)	Immune regulation, T cell activation, apoptosis, and glucose metabolism	T cells, B cells, NK cells, macrophages
CD33	Sialic acid binding Ig-like lectin 3 (Siglec-3)	Sialic acid dependent binding, apoptosis in AML	Myeloid cells, few lymphoid cells
CD47	Integrin associated protein (IAP)	Apoptosis, proliferation, adhesion, migration, and immune recognition; phagocytosis block	T cells, B cells, NK cells, macrophages, progenitor cells, and many others
CD96	T cell activation, increased late expression (Tactile)	Immune adhesion, antigen presentation	T cells, NK cells, some B cells
CD123	IL-3R	Proliferation and differentiation during hematopoiesis	Hematopoietic progenitor cells
CLL-1	C-type lectin-like molecule 1, C-type lectin domain family 12 member A (CLEC12A)	Cell adhesion, cell-cell signaling, inflammation, and immune responses	Monocytes, macrophages, dendritic cells, granulocytes
TIM3	T cell immunoglobulin mucin-3	Autoimmunity and allergy	Th1 cells