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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Eur J Cell Biol. 2016 Jun 25;95(11):449–464. doi: 10.1016/j.ejcb.2016.06.007

Figure 2. Connections between lamin A/C and pathways known to suppress or promote cancer formation and progression.

Figure 2

Lamin A/C participates in many pathways characterized to have oncogenic (red) or tumour suppressor (blue) functions in cancer. Lamin A/C expression influences protein levels or downstream activity to modulate signal transduction, and in many cases interactions between lamin A/C and signalling proteins have also been detected (double lines). It is important to note that many of these functions have been identified in lamin A/C mutant or deletion models for laminopathies, and an understanding of lamin A/C-related signalling in the context of cancer demands further study.