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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Eur J Cell Biol. 2016 Jun 25;95(11):449–464. doi: 10.1016/j.ejcb.2016.06.007

Figure 4. Potential roles for lamin A/C in tumour initiation and progression.

Figure 4

Both increased and decreased levels of lamin A/C have been observed in cancer and related to patient prognosis. The complexity of lamin A/C functions and signalling networks suggests that the role of lamin A/C in tumour progression may vary with stage of disease, tissue of origin, and mutational landscape of a given tumour. Possible functions for increased and decreased lamin A/C levels during tumour progression are depicted here, and warrant further investigation towards understanding the role of lamin A/C in cancer. Importantly, many of these lamin-related functions could contribute to multiple stages of cancer, but are each shown here only once for simplicity.