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Evidence of positive association between estrogen and RP. Accumulating evidence points to an overwhelming association between estrogen and RP. For instance, estrogen increases α2C-AR but not α2A-AR in human arteriolar smooth muscle cells. Moreover, females have higher expression of α2C-AR than males. Epidemiologically, RP is reported to have remarkably high incidence in premenopausal females or post-menopausal females on estrogen replacement therapy (ERT).
