Table 1.

Various lines of treatment of Raynaud’s disease.

	Treatment	Effectiveness	Reference
Traditional treatment	Calcium channel blockers	Effective; first-line of treatment	Halawa, 2001; Thompson and Pope, 2005
	PTK inhibitors	Efficient	Furspan et al., 2004, 2005
	PDE5 inhibitors	Inefficient	Lee et al., 2014
	Beta-blockers	Controversial	Marshall et al., 1976 Koltringer et al., 1991
	Statins	Emerging/powerful	Abou-Raya et al., 2008
	Prostacyclins	Efficient	Rademaker et al., 1987
	ACE inhibitors	Variable effect	Henness and Wigley, 2007
	Endothelin receptor antagonists	Variable effect	Poredos and Poredos, 2016
	Serotonin receptor antagonists	Effective	Coleiro et al., 2001
Non-Traditional treatment	Botulinum toxin type A	Efficient	Neumeister et al., 2014
	Chinese herb	Ineffective	Wu et al., 2008
	Ginkgo biloba	Ineffective	Muir et al., 2002
	Acupuncture	Efficient	Appiah et al., 1997
	Laser therapy	Efficient	Hirschl et al., 2004
Surgery	Thoracic sympathectomy	Effective	Coveliers et al., 2011
	Hand stripping	Effective	Balogh et al., 2002
	Nerve stimulation	effective	Kaada, 1982
	Fat grafting	Encouraging results	Bank et al., 2014

A summary of the traditional and non-traditional therapies, as well as some surgical interventions.