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. 2016 Nov 16;7:203. doi: 10.3389/fneur.2016.00203

Figure 1.

Figure 1

MRI of patient 1.1 at 9 years (A–D) and 12 years (E–H). The first MRI shows signal abnormalities in the middle blade of the corpus callosum [(A,C) and inset in (A)]; inhomogeneous mainly multifocal signal abnormalities in the subcortical and deep cerebral white matter, sparing a periventricular rim (C,D); and slight cerebral (C,D) but no cerebellar atrophy (A,B). At follow-up, slightly increased cerebral and cerebellar atrophy is seen. MRI of patient 2 at 4 years (I–L) and 20 years (M–P). The first MRI shows signal abnormalities in the middle blade of the corpus callosum (I,K), inhomogeneous, mainly confluent signal abnormalities in the subcortical and deep cerebral white matter, sparing a periventricular rim (K,L) and no cerebral or cerebellar atrophy (I–L). At follow-up, severe cerebral and milder cerebellar atrophy is seen (M–P). The corpus callosum is highly atrophic, but the selective involvement of the middle blade is still seen [inset in (O)]. Within the posterior fossa, signal abnormalities are present in the middle cerebellar peduncles and pontine central tegmental tracts (N).