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Act-αMSH is more potent than Des-αMSH in stimulating cAMP in 293T cells expressing MC4R. Shown are dose responses (A and C) and time courses (B and D) of Des-αMSH (open circles) or Act-αMSH (filled circles) used to induce cAMP. (A and B) IBMX pretreatment (30 min). (C and D) Absence of IBMX. Significant differences were determined by ANOVA and Student's t test for post hoc analysis. *, P < 0.05; **, P < 0.005.
