Table 4.
Number of genes significantly affected in S. pneumoniae D39 ΔccpA compared to the D39 wild-type grown in CDM with 0.5% NAG.
| Functional categories | Total | Up | Down |
|---|---|---|---|
| C: Energy production and conversion | 10 | 4 | 6 |
| D: Cell cycle control, cell division, chromosome partitioning | 2 | 0 | 2 |
| E: Amino acid transport and metabolism | 4 | 3 | 1 |
| F: Nucleotide transport and metabolism | 1 | 0 | 1 |
| G: Carbohydrate transport and metabolism | 19 | 17 | 2 |
| H: Coenzyme transport and metabolism | 1 | 0 | 1 |
| I: Lipid transport and metabolism | 3 | 0 | 3 |
| J: Translation, ribosomal structure and biogenesis | 15 | 3 | 12 |
| K: Transcription | 3 | 2 | 1 |
| L: Replication, recombination and repair | 3 | 2 | 1 |
| M: Cell wall/membrane/envelope biogenesis | 6 | 2 | 4 |
| O: Posttranslational modification, protein turnover, chaperones | 3 | 3 | 0 |
| P: Inorganic ion transport and metabolism | 3 | 1 | 2 |
| Q: Secondary metabolites biosynthesis, transport and catabolism | 2 | 1 | 1 |
| R: General function prediction only | 5 | 3 | 2 |
| S: Function unknown | 42 | 22 | 20 |
| T: Signal transduction mechanisms | 3 | 3 | 0 |
| U: Intracellular trafficking, secretion, and vesicular transport | 2 | 2 | 0 |
| V: Defense mechanisms | 8 | 7 | 1 |
| Others | 34 | 19 | 15 |
| Total number of genes | 169 | 94 | 75 |
Genes affected with more than 2-fold in D39 ΔccpA compared to the D39 wild-type are shown in COG functional categories.