Table 3.
Changes in quality-of-life measurements after the start of non-invasive ventilation
| ALS group | Non-ALS group | Between groups | |||||
|---|---|---|---|---|---|---|---|
| Baseline, N = 29 | Change 0–2 months, N = 26 | Change 0–6 months, N = 22 | Baseline, N = 47 | Change 0–2 months, N = 41 | Change 0–6 months, N = 43 | P value for difference in change 0–6 months | |
| SRI | |||||||
| Respiratory complaints | 42.0 ± 16.8 | 6.7 ± 3.0* | 2.0 ± 4.2 | 51.9 ± 19.5 | 9.7 ± 2.0 | 7.3 ± 2.0* | 0.194 |
| Physical functioning | 21.0 ± 18.4 | −3.0 ± 2.8 | −7.9 ± 4.5 | 40.0 ± 19.7 | 2.9 ± 2.1 | 1.8 ± 3.0 | 0.075 |
| Attendant symptoms/sleep | 49.5 ± 14.6 | 15.2 ± 3.4* | 15.6 ± 4.1* | 53.3 ± 21.3 | 6.5 ± 2.3 | 11.4 ± 2.5* | 0.363 |
| Social relationship | 68.2 ± 10.2 | −0.6 ± 2.1 | −6.3 ± 1.7* | 70.9 ± 13.8 | 1.2 ± 2.0 | 1.3 ± 2.3 | 0.032¶ |
| Anxiety | 47.4 ± 12.1 | 6.9 ± 2.7* | −6.4 ± 4.2 | 59.5 ± 21.0 | 4.3 ± 2.5 | 9.0 ± 2.6* | 0.002¶ |
| Well-being | 51.2 ± 17.4 | 1.8 ± 2.6 | 0.4 ± 2.8 | 63.5 ± 16.6 | 1.0 ± 2.0 | −0.1 ± 1.9 | 0.899 |
| Social functioning | 44.5 ± 13.7 | −2.7 ± 2.5 | −7.1 ± 3.0* | 61.5 ± 18.0 | 1.4 ± 2.0 | 1.1 ± 2.1 | 0.027¶ |
| Summary score | 46.3 ± 8.7 | 3.5 ± 1.8 | −1.4 ± 2.4 | 57.2 ± 14.0 | 3.9 ± 1.3* | 4.5 ± 1.6* | 0.037¶ |
| MRF-28 | |||||||
| Daily activities | 74.0 ± 24.9 | 4.1 ± 2.4 | 5.4 ± 5.7 | 51.8 ± 29.2 | −8.7 ± 3.6 | −7.4 ± 4.3 | 0.083 |
| Cognition | 34.5 ± 33.0 | −9.6 ± 6.2 | −4.1 ± 6.2 | 37.8 ± 34.9 | −9.7 ± 4.6* | −7.6 ± 4.8 | 0.675 |
| Invalidity | 73.1 ± 31.7 | −2.3 ± 6.0 | 2.7 ± 5.8 | 44.2 ± 35.1 | −2.9 ± 5.0 | 4.2 ± 5.5 | 0.867 |
| Total score | 64.2 ± 17.9 | −4.7 ± 2.4 | −1.4 ± 4.2 | 50.2 ± 22.1 | −13.0 ± 2.9* | −11.9 ± 2.9* | 0.041¶ |
| HADS | |||||||
| Depression | 8.3 ± 7.2 | −0.2 ± 0.6 | 1.0 ± 0.6 | 6.3 ± 3.8 | −1.3 ± 0.4* | −1.6 ± 0.4* | 0.001¶ |
| Anxiety | 7.3 ± 4.3 | 0.2 ± 0.6 | 0.8 ± 0.7 | 6.3 ± 4.0 | −1.2 ± 0.5* | −1.1 ± 0.4* | 0.017¶ |
| Total score | 15.6 ± 7.2 | −0.0 ± 1.1 | 1.8 ± 1.1 | 12.6 ± 7.2 | −2.5 ± 0.8* | −2.7 ± 0.7* | 0.001¶ |
| SF-36 | |||||||
| Physical functioning | 10.3 ± 17.6 | −1.0 ± 1.4 | −7.1 ± 3.2* | 18.2 ± 21.5 | 4.0 ± 1.3* | 4.4 ± 2.0* | 0.002¶ |
| Role physical | 6.0 ± 12.7 | 1.9 ± 4.6 | −4.8 ± 3.3 | 19.7 ± 34.9 | 6.1 ± 6.0 | 17.4 ± 7.0* | 0.036¶ |
| Bodily pain | 66.9 ± 25.4 | −3.8 ± 5.0 | −11.4 ± 7.4 | 64.8 ± 32.5 | −0.3 ± 4.4 | 3.0 ± 4.1 | 0.071 |
| General health | 19.6 ± 13.6 | −0.3 ± 3.1 | −3.0 ± 2.8 | 37.2 ± 22.4 | 2.5 ± 2.6 | 7.6 ± 3.1* | 0.031¶ |
| Vitality | 33.6 ± 17.3 | 3.1 ± 3.9 | 4.3 ± 4.0 | 40.4 ± 21.4 | 10.6 ± 3.1* | 13.3 ± 2.7* | 0.065 |
| Social functioning | 44.4 ± 27.7 | 2.9 ± 6.3 | −13.6 ± 5.9* | 59.8 ± 26.5 | 4.6 ± 3.7 | 11.3 ± 4.0* | 0.001¶ |
| Role emotional | 59.8 ± 45.7 | −1.3 ± 12.8 | −14.3 ± 8.5 | 46.1 ± 51.3 | 13.0 ± 9.4 | 20.9 ± 9.1* | 0.017¶ |
| Mental health | 64.4 ± 20.4 | −0.5 ± 2.4 | 0.5 ± 3.2 | 66.2 ± 19.4 | 6.0 ± 2.0* | 8.6 ± 2.5* | 0.050 |
| Physical component summary | 25.7 ± 10.2 | −0.8 ± 2.3 | −6.8 ± 2.4* | 34.5 ± 16.7 | 3.1 ± 2.1 | 8.1 ± 2.8* | 0.001¶ |
| Mental component summary | 49.4 ± 28.2 | 1.0 ± 7.6 | −9.5 ± 5.3 | 47.2 ± 31.8 | 10.3 ± 5.6 | 16.6 ± 5.5* | 0.004¶ |
Baseline data are presented as mean ± standard deviation
Change over time are presented as mean ± standard error of mean
¶ p < 0.05 for difference in change between groups 0–6 months
* p < 0.05 for changes within groups from baseline
SRI Severe Respiratory Insufficiency (0 = worst possible health; 100 = best possible health), MRF-28 Maugeri Respiratory Failure (0 = best possible health; 100 = worst possible health), HADS Hospital Anxiety Depression Scale (0 = best possible score; 42 = worst possible score), SF-36 Short-Form Health Status Survey (0 = worst possible health; 100 = best possible health)