Table 2.
Degrees of freedom of the dOFV distributions for the real data and simulation examples
| Real data examples | Df Chi square (theoretical) | Df original | Df sim 1× median (range) |
Df sim 8× median (range) |
|---|---|---|---|---|
| Phenobarbital [11] | 7 | 11.4 | 8.81 (6.86, 14.3) | 7.35 (6.45, 8.45) |
| Pefloxacin [12] | 10 | 16.5 | 11.3 (8.48, 14.0) | 10.0 (9.78, 10.9) |
| Simulation examples | Df Chi square (theoretical) | Df 20-4 median (range) |
Df 50-4 median (range) |
Df 200-4 median (range) |
|---|---|---|---|---|
| Simulation 1 (PK) | 5 | 6.25 (4.32, 10.6) | 5.48 (4.10, 7.15) | 5.07 (4.42, 5.94) |
| Simulation 2 (PD) | 7 | 8.39 (5.74, 14.4) | 7.55 (6.22, 9.93) | 7.15 (6.24, 8.08) |