Table 1. HPA axis activity.
| Component | WT | GRov |
|---|---|---|
| Corticosterone, μg/dl | ||
| Morning | 0.42 ± 0.20 | 0.64 ± 0.20 |
| Evening | 5.67 ± 0.70 | 5.04 ± 1.06 |
| EPM | 3.84 ± 0.22 | 4.07 ± 0.25 |
| Post | 6.70 ± 0.47 | 6.51 ± 0.57 |
| Plasma ACTH, pg/ml | ||
| Morning | 6.01 ± 1.14 | 7.64 ± 1.32 |
| Evening | 19.72 ± 5.21 | 22.51 ± 7.78 |
| EPM | 137.08 ± 14.63 | 94.27 ± 18.54 |
| Post | 123.46 ± 18.27 | 80.23 ± 17.39 |
| Basal proopiomelanocortin mRNA in the anterior pituitary | 24,527 ± 2,637 | 24,383 ± 2,532 |
| Basal CRH mRNA in the PVN | 2,184 ± 109 | 2,405 ± 147 |
| Basal mineralocorticoid receptor mRNA in the HC | 9,870 ± 259 | 10,015 ± 480 |
Proopiomelanocortin, CRH, and mineralocorticoid receptor mRNAs are given in integrated optical density. EPM values were obtained immediately after EPM exploration. Post values were obtained 10 min after EPM exploration. Results are expressed as mean ± SEM with n ≥ 5 per genotype.