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. 2016 Nov 2;2016:7861653. doi: 10.1155/2016/7861653

Figure 11.

Figure 11

Effects of 30 μM E3G on ventricular cell action potentials for Nav1.5-WT and Nav1.5-p.I141V conditions (TNNP cell model). (a), (b), and (c) Simulated APs (Top of the panels) and the cardiac sodium currents (Bottom of the panels) in WT, heterozygous Nav1.5-p.I141V, and heterozygous Nav1.5-p.I141V + 30 μM conditions at 1 Hz cycle length. Arrows: external stimulus. (d) and (e) Strength-duration curves in the TNNP cell model for Nav1.5-WT and heterozygous Nav1.5-p.I141V conditions with or without 30 μM E3G (inset, zoom on the strength-duration curves). (f) Excitation thresholds at 2 ms stimulus duration in the TNNP atrial AP or without 30 μM E3G.