Table 2.
Formulation of WT and mutated sodium channels (Nav1.5-p.R222Q and Nav1.5-p.I141V) in the presence or absence of 30 µM of E3G in the Maleckar-Greenstein-Trayanova-Giles atrial cell model. The bold font corresponds to mutations effect and the bold-italic font to E3G effects.
| MGTG atrial model, p.R222Q.I Na | MGTG atrial model, p.I141V.I Na | MGTG atrial model, I CaL | MGTG atrial model, I Ks | |
|---|---|---|---|---|
| WT | m ∞, WT (V m) = m ∞, WT (V m) | m ∞, WT (V m) = m ∞, WT (V m) | 100% of I CaL | 100% of I Ks |
|
m factor, WT (V
m) = m factor, WT (V
m) τ m = 4.2e − 5 (s)∗exp(−m factor ∗m factor) + 2.4e − 5 (s) |
m factor, WT (V
m) = m factor, WT (V
m) τ m = 4.2e − 5 (s)∗exp(−m factor ∗m factor) + 2.4e − 5 (s) |
|||
| h ∞, WT (V m) = h ∞, WT (V m) | h ∞, WT (V m) = h ∞, WT (V m) | |||
| h factor, WT (V m) = h factor, WT (V m) | h factor, WT (V m) = h factor, WT (V m) | |||
| τ h1 = 0.03 (s) ∗h factor + 0.0003 (s) | τ h1 = 0.03 (s) ∗ h factor + 0.0003 (s) | |||
|
| ||||
| WT + 30 µM E3G | m ∞, WT (V m) = m ∞, WT (V m) | m ∞, WT (V m) = m ∞, WT (V m) | 80% of I CaL | 50% of I Ks |
|
m factor, WT (V
m) = m factor, WT (V m) |
m factor, WT (V m) = m factor, WT (V m) | |||
| τ m = 4.2e − 5 (s)∗exp(−m factor ∗m factor) + 2.4e − 5 (s) | τ m = 4.2e − 5 (s)∗exp(−m factor ∗m factor) + 2.4e − 5 (s) | |||
| h ∞, WT (V m) = h ∞, WT (V m + 6) | h ∞, WT (V m) = h ∞, WT (V m + 6) | |||
| h factor, WT (V m) = h factor, WT (V m) | h factor, WT (V m) = h factor, WT (V m) | |||
| τ h1 = 0.03 (s) ∗ h factor + 0.0003 (s) | τ h1 = 0.03 (s) ∗ h factor + 0.0003 (s) | |||
|
| ||||
| Mutants | m ∞, WT (V m) = m ∞, WT (V m + 6.3) | m ∞, WT (V m) = m ∞, WT (V m + 7) | 100% of I CaL | 100% of I Ks |
| m factor, WT (V m) = m factor, WT (V m) | m factor, WT (V m) = m factor, WT (V m + 7) | |||
| τ m = 4.2e − 5 (s)∗exp(−m factor ∗m factor) + 2.4e − 5 (s) | τ m = 4.2e − 5 (s)∗exp(−m factor ∗m factor) + 2.4e − 5 (s) | |||
| h ∞, WT (V m) = h ∞, WT (V m + 6.2) | h ∞, WT (V m) = h ∞, WT (V m) | |||
| h factor, WT (V m) = h factor, WT (V m) | h factor, WT (V m) = h factor, WT (V m + 7) | |||
| τ h1 = 0.03 (s) ∗ h factor + 0.0003 (s) | τ h1 = 0.03 (s) ∗ h factor + 0.0003 (s) | |||
|
| ||||
| Mutants + 30 µM E3G | m ∞, WT (V m) = m ∞, WT (V m + 6.3) | m ∞, WT (V m) = m ∞, WT (V m + 7) | 80% of I CaL | 50% of I Ks |
| m factor, WT (V m) = m factor, WT (V m) | m factor, WT (V m) = m factor, WT (V m + 7) | |||
| τ m = 4.2e − 5 (s)∗exp(−m factor ∗m factor) + 2.4e − 5 (s) | τ m = 4.2e − 5 (s)∗exp(−m factor ∗m factor) + 2.4e − 5 (s) | |||
| h ∞, WT (V m) = h ∞, WT (V m + 6.2 + 6) | h ∞, WT (V m) = h ∞, WT (V m + 6) | |||
| h factor, WT (V m) = h factor, WT (V m) | h factor, WT (V m) = h factor, WT (V m + 7) | |||
| τ h1 = 0.03 (s) ∗ h factor + 0.0003 (s) | τ h1 = 0.03 (s) ∗ h factor + 0.0003 (s) | |||