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. 2016 Nov 2;2016:7861653. doi: 10.1155/2016/7861653

Table 4.

The effect of E3G on conduction velocity investigations in the presence of p.R222Q and p.I141V in heterozygous states.

Model Atrial cells Ventricular cells Purkinje cells
Condition CV (cm/s)
control
CV (cm/s)
30 µM E3G
CV (cm/s)
control
CV (cm/s)
30 µM E3G
CV (cm/s)
control
CV (cm/s)
30 µM E3G
Nav1.5 WT 55.07 50.84 49.91 45.72 67.68 37.20
Nav1.5 p.I141V 57.44 53.93 53.63 49.11 72.43 42. 92
Nav1.5 p.R222Q 60.93 56.23 51.93 45.56 62.72