Figure 3.

The Dll4in3 enhancer requires MEF2 binding to direct expression during adult neovascularization. (A) Representative images of Dll4in3:LacZ transgene expression during neovascularization into Matrigel plugs and B16F10 melanoma tumors demonstrate robust vascular X-gal staining. (B) Representative images of the mutant Dll4in3mutMEF:LacZ transgene demonstrate that the mutated enhancer was unable to direct any detectable reporter gene expression during adult neovascularization. See also Supplemental Figure 3.