Table 3. Differentially methylated regions (DMRs) are enriched for miRNA profiles.
| DMRs | miRNA | Positive hitsa | Negative hitsa | Fold enrichment | AME FDR |
|---|---|---|---|---|---|
| Caste-biased | Zne-mir-34-3p | 55 | 0 | 103.337 | 8.97E-13 |
| Zne-mir-263a-3p | 24 | 0 | 45.092 | 1.11E-10 | |
| Zne-mir-6012-5p | 267 | 16 | 31.353 | 3.03E-15 | |
| Zne-mir-2a-3-5p | 10 | 0 | 18.788 | 1.39E-11 | |
| Zne-mir-125-5p | 10 | 0 | 18.788 | 1.54E-02 | |
| Zne-mir-2796-3p | 5 | 0 | 9.394 | 4.38E-02 | |
| Zne-mir-279c-5p | 4 | 0 | 7.515 | 5.97E-10 | |
| Zne-mir-3049-5p | 4 | 0 | 7.515 | 4.41E-06 | |
| Zne-mir-87-1-3p | 14 | 4 | 6.576 | 1.43E-05 | |
| Zne-mir-981-5p | 3 | 0 | 5.637 | 1.57E-12 | |
| all miRNAsb | 556 | 136 | 7.681 | ||
| Sex-biased | Zne-mir-34-3p | 19 | 0 | 35.005 | 4.68E-04 |
| Zne-mir-275-3p | 9 | 0 | 16.581 | 4.13E-04 | |
| Zne-mir-998-5p | 7 | 0 | 12.897 | 6.44E-03 | |
| Zne-mir-750-5p | 6 | 0 | 11.054 | 3.80E-02 | |
| Zne-bantam-5p | 14 | 4 | 6.448 | 3.72E-02 | |
| Zne-mir-6012-3p | 3 | 0 | 5.527 | 1.58E-02 | |
| Zne-mir-278-5p | 3 | 0 | 5.527 | 1.79E-02 | |
| Zne-mir-981-5p | 2 | 0 | 3.685 | 1.09E-05 | |
| Zne-mir-279c-5p | 2 | 0 | 3.685 | 1.67E-02 | |
| Zne-mir-184-5p | 1 | 0 | 1.842 | 3.45E-05 | |
| all miRNAsb | 222 | 110 | 3.718 |
Top 10 miRNA sequences showing overrepresentation among sequences surrounding caste- and sex-biased differentially methylated cytosines.
aThe number of significant hits (FIMO) for the given miRNA among caste- and sex-biased DMRs (+hits) as well control sequences–N positive set, caste: 5,786, sex: 1,364; N negative set, caste: 10,871, sex: 2,513.
bThe number of positive and negative set sequences featuring a significant hit to any miRNA.