Table 1. Preliminary screening of mixed micelle formation with various ratios of different amphiphiles (NaDOC; TPGS; PLURONIC P123, F68, F87, F127, F108, and L121; CREMOPHOR RH40 and ELP) and lecithin.
| Amphiphiles (HLB) | Curcumin:Lecithin:Amphiphile |
|||||
|---|---|---|---|---|---|---|
| 1:0:5 | 1:1:5 | 1:0:10 | 1:1:10 | 1:0:20 | 1:1:20 | |
| NaDOC (16) | 104.4 ± 2.23a (0.691 ± 0.045)b | 91.1 ± 4.77 (0.564 ± 0.006) | 109.9 ± 4.96 (0.498 ± 0.169) | 78.8 ± 2.59 (0.294 ± 0.098) | 111.6 ± 4.24 (0.327 ± 0.021) | 132.7 ± 1.82 (0.308 ± 0.042) |
| TPGS (13) | 145.9 ± 49.35 c (1.457 ± 0.311) | 286.9 ± 21.26 (1.250 ± 0.153) | 44.3 ± 27.11 (−6.385 ± 5.218) | 49.6 ± 2.98 (1.140 ± 0.109) | 43.8 ± 1.20 (0.708 ± 0.181) | 47.2 ± 6.54 (1.583 ± 0.040) |
| F68 ( > 24) | 131.5 ± 10.60 (0.230 ± 0.039) | 403.1 ± 83.86 (0.943 ± 0.192) | 83.1 ± 23.36 (0.107 ± 0.062) | 270.1 ± 6.86 (0.967 ± 0.022) | 139.6 ± 59.21 (1.221 ± 0.437) | 338.2 ± 10.73 (0.756 ± 0.084) |
| F108 ( > 24) | 279.8 ± 203.15 (1.728 ± 0.176) | 800.0 ± 20.98 (1.134 ± 0.132) | 126.6 ± 28.23 (1.310 ± 0.559) | 430.7 ± 10.12 (1.314 ± 0.023) | 279.8 ± 203.15 (1.728 ± 0.176) | 316.9 ± 5.00 (1.061 ± 0.014) |
| F87 ( > 24) | 67.0 ± 3.62 (0.303 ± 0.093) | 410.8 ± 5.32 (0.627 ± 0.052) | 67.5 ± 11.12 (1.579 ± 0.069) | 488.3 ± 38.48 (0.888 ± 0.084) | 47.3 ± 21.23 (1.435 ± 0.136) | 596.0 ± 118.27 (1.042 ± 0.044) |
| F127 (18–23) | 92.1 ± 74.83 (−0.293 ± 1.562) | 546.4 ± 95.08 (1.183 ± 0.250) | 36.6 ± 5.89 (−0.060 ± 0.730) | 421.3 ± 16.91 (0.905 ± 0.104) | 244.6 ± 40.43 (1.680 ± 0.180) | 322.9 ± 4.20 (1.419 ± 0.069) |
| L121 (1–7) | >3000 | >3000 | >3000 | >3000 | >3000 | >3000 |
| P123 (7–9) | 111.2 ± 1.52 (0.334 ± 0.043) | 106.1 ± 0.84 (0.820 ± 0.035) | 85.1 ± 4.11 (1.236 ± 0.157) | 622.8 ± 68.14 (1.881 ± 0.161) | 69.1 ± 3.04 (1.376 ± 0.085) | 257.8 ± 43.38 (2.116 ± 0.062) |
| RH40 (14.3) | 257.4 ± 57.46 (−0.060 ± 0.037) | 264.1 ± 73.32 (0.860 ± 0.313) | 71.5 ± 101.12 (0.021 ± 0.353) | 742.1 ± 87.89 (−3.450 ± 1.025) | 43.0 ± 18.65 (1.294 ± 0.414) | 208.9 ± 11.63 (1.960 ± 0.071) |
| ELP (13.9) | 290.9 ± 6.50 (0.598 ± 0.031) | 429.8 ± 9.48 (1.617 ± 0.017) | 42.6 ± 36.48 (0.527 ± 0.666) | 534.3 ± 206.48 (1.392 ± 0.174) | 25.4 ± 11.79 (1.619 ± 0.174) | 216.0 ± 1.14 (0.372 ± 0.024) |
aMean size ± SD.
bMean PI ± SD.
cUnderline stander for precipitation during 12 hr.